Radioguided surgery with radiolabeled somatostatin analogs: not only in GEP-NETs
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چکیده
منابع مشابه
Receptor affinity and preclinical biodistribution of radiolabeled somatostatin analogs.
In this study, we investigated the relationship between affinity to somatostatin receptor subtype2 (SSTR(2)) and uptake of radioactivity from a group of radiolabeled somatostatin analogues in somatostatin receptor-rich tissues of rats. Organs with a high density of somatostin receptors (namely the adrenals and pancreas bearing mainly SSTR(2); this receptor subtype is also the most abundant in s...
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Somatostatin (SST) is a 28-amino-acid cyclic neuropeptide mainly secreted by neurons and endocrine cells. A major interest for SST receptors (SSTR) as target for in vivo diagnostic and therapeutic purposes was born since a series of stable synthetic SST-analouges PET became available, being the native somatostatin non feasible for clinical use due to the very low metabolic stability. The ration...
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We present a sarcoma patient with a tumor reduction of more than 50% in lung metastasis after 2 single courses of the investigational medical product Lutathera (Lu-DOTA0-Tyr3-octreotate). She was resistant to more than 6 lines of therapy including all the available active drugs in soft tissue sarcomas. The high expression of somatostatin receptors was shown by microarrays and Octreoscan. The ov...
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In this issue of The Journal of Nuclear Medicine, Wild et al. report the binding and animal biodistribution data of [Lys(Ahx-DTPA-In)NH2]exendin-4 (Ahx is aminohexanoic acid; DTPA is diethylenetriaminepentaacetic acid), an analog of glucagonlike peptide-1 (GLP-1) (1). Their results raise high hopes of actually achieving selective and potent receptormediated targeting of tumors with a radiolabel...
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In patients with progressive metastatic (or recurrent) differentiated thyroid carcinoma that either do not take up radioiodine or are unresponsive to continued radioiodine therapy, staging is difficult and treatment options are few. However, in most of these patients uptake of radiolabeled somatostatin analogs is evident on somatostatin-receptor scintigraphy (SRS). Using SRS, patients with suff...
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ژورنال
عنوان ژورنال: Nuclear Medicine Review
سال: 2017
ISSN: 1644-4345,1506-9680
DOI: 10.5603/nmr.2017.0003